In a rabbit model of acute synovitis, the selective removal of large immune complexes from the knee joint depends on the influx of neutrophils.
Neutrophil-dependent clearance of large immune complexes in rabbit joints may inform synovitis models; leaves open relevance to human arthritis.
Large antigen‐antibody complexes that are selectively removed from circulation were not selectively removed when injected into the knees of a normal rabbit. The subsequent selective removal of the complexes depended on the influx of neutrophils. Nevertheless, macrophages of the normal synovial lining were able to phagocytize some immune complexes. When antigen and antibodies were administered separately by intravenous or intraarticular routes, little or no soluble complexes were found in synovial fluid, and most of the antigen‐antibody union was thought to occur in the synovial tissue.
No takes yet. Share an insight, caveat, or question.
Hollister et al. (1973) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: