Why the study?
Bleomycin is an effective chemotherapeutic agent, but lung fibrosis limits its clinical use, prompting investigation into protective strategies.
Does grape seed and skin extract pre-treatment prevent bleomycin-induced lung fibrosis and inflammation in a rat model?
Does grape seed and skin extract pre-treatment prevent bleomycin-induced lung fibrosis and inflammation in a rat model?
Grape seed and skin extract demonstrates antioxidant, anti-inflammatory, and anti-fibrotic properties that protect against bleomycin-induced lung damage in rats.
Introduction: Bleomycin is an effective chemotherapeutic agent with main side effects including lung fibrosis which limited its clinical use. The aim of this study is to evaluate the protective effect of grape seed and skin extract (GSSE) against bleomycin-induced oxidative damage and inflammation in rat lung, by assessing respiratory index (RI), oxidative and nitrosative stress (SOD and XO activity, NO), fibrotic mediators (hydroxyproline and collagen), apoptosis (cytochrome C and LDH), inflammation (IL-6, TNF-α and TGF-β1), and histological disturbances. Methods: Bleo disturbed lung function through the accumulation of hydroxyproline and collagen, decreased SOD activity but increased XO activity as well as GSH and NO levels. Bleo also increased the pro-inflammatory cytokines IL-6, TNF-α, and TGF-β1, and pro-apoptotic cytochrome C factor and induced severe histological alterations of lung parenchyma. Interestingly GSSE pre-treatment efficiently counteracted most of the bleo-induced lung tissue damages. Conclusion: Data suggest that GSSE exerts anti-oxidant, ant-inflammatory, and anti-fibrosis properties that could find potential application in the protection against bleo-induced lung fibrosis.
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Khazri et al. (2022) studied this question.
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