Two arms to hold: Inspired by the structure of basic leucine-zipper proteins, high-affinity peptides, named aptides, were designed that contain a stabilizing scaffold (tryptophan zipper) and two target-binding regions (orange and blue in picture). A fluorescently labeled aptide that binds to a tumor-specific protein was used for fluorescence imaging in vivo.
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Kim et al. (2012) studied this question.
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