Open wide and say AAA: The copper-free asymmetric allylic alkylation reaction of Grignard reagents, catalyzed by N-heterocyclic carbenes, is reported for allyl bromide derivatives. This reaction offers good enantioselectivity and good to excellent γ regioselectivity, particularly for the formation of quaternary chiral centers (see scheme; Mes=mesityl).
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Jackowski et al. (2010) studied this question.
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