Laboratory study demonstrates the synthesis of hindered alkyl fluorides via dual activation of organoborons, indicating an efficient ion-pair strategy under mild conditions.
A novel electrochemical approach for the synthesis of hindered alkyl fluorides has been developed. The protocol grants access to a diverse array of tertiary and secondary alkyl fluorides using readily attainable organoboron precursors under mild conditions. The efficiency of the system stems from the dual activation of the redox-active borate intermediate, providing both electrophilic and nucleophilic reaction partners in the form of an internally generated ion pair.
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Kim et al. (2025) studied this question.
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