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Final differentiation of an erythroid-megakaryocyte precursor cell into one or the other lineage may involve a balance between 2 related transcription factors, NF-E2, which leads to megakaryocytic differentiation, and BACH1, which leads to erythroid differentiation.The effect of BACH1/NF-E2 ratio on lineage selection for a common erythroid-megakaryocyteprecursor.
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Mortimer Poncz (2005) studied this question.
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