Exploring a genetic basis for the metabolic perturbations in ME/CFS using UK biobank

This is the authors' abstract. We don't add key points for this paper.

, which are involved in immune regulation. ME/CFS mGWAS summary statistics were decomposed to uncover shared genetic-metabolic patterns, where enrichment analysis highlighted pathways in lipid metabolism, neurotransmitter transport, and inflammation. These findings provide a genetic and molecular rationale for patient heterogeneity and suggest a polygenic predisposition in which many small-effect variants may jointly perturb metabolic mechanisms.