Key result
Astragaloside inhibited cardiomyocyte apoptosis and the expression of various apoptosis-associated genes in mice with coxsackievirus B3-induced myocarditis.
Why the study?
Does astragaloside reduce cardiomyocyte apoptosis in mice with coxsackievirus B3-induced myocarditis?
Does astragaloside reduce cardiomyocyte apoptosis in mice with coxsackievirus B3-induced myocarditis?
Astragaloside inhibits cardiomyocyte apoptosis in a murine model of coxsackievirus B3-induced myocarditis, providing a potential mechanism for its therapeutic effects.
Supports further preclinical study of astragaloside in viral myocarditis; leaves open translation to human therapy.
Astragaloside is the major component of Astragalus membranaceus, one of the Chinese medical herbs, and has several pharmacological actions on cardiovascular system, including positive inotropic, anti-arrhythmia and anti-oxidant activities. We have investigated the effect of astragaloside on cardiomyocyte apoptosis and expression of apoptosis-associated genes in mice with coxsackievirus B(3) (CVB(3))-induced myocarditis, the former of which has been detected by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end-labeling (TUNEL) assay and the latter determined by using a focused microarray. Results showed that cardiomyocyte apoptosis and expression of various apoptosis associated genes are inhibited after treatment with astragaloside. The anti-apoptotic activity of astragaloside may contribute to the improvement of clinical outcomes in treating myocarditis with pharmaceutics of Astragalus membranaceus.
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Zhang et al. (2007) studied coxsackievirus B3-induced myocarditis. astragaloside was evaluated on cardiomyocyte apoptosis and expression of apoptosis-associated genes. Astragaloside inhibited cardiomyocyte apoptosis and the expression of various apoptosis-associated genes in mice with coxsackievirus B3-induced myocarditis.
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