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It has been over 25 years since the first observations that cells of the immune system could influence the functions of bone cells. Since that time, significant strides have been made in our understanding of the role of the immune system in bone cell activity. A number of recent discoveries demonstrated that a variety of cytokines and growth factors can influence the function of both bone and immune cells, advancing our knowledge of the interactions of these cellular systems, but important questions remain to be answered before we can fully appreciate the intricacies of the relationship between immune and bone cells.
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Joseph Lorenzo (2000) studied this question.
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