Key result
Selective inhibition of COX-1 reduced lesion formation in the early stages of atherosclerosis in apoE-/- mice, whereas COX-2 inhibition had no effect on lesion development.
Why the study?
Does selective inhibition of COX-1 or COX-2 reduce atherosclerosis development and platelet vessel wall interactions in apoE-/- mice?
Population
Apolipoprotein E-deficient (apoE-/-) mice fed a 1% cholesterol diet
Comparison
Selective COX-1 inhibitor or selective COX-2… vs Vehicle
Design
Preclinical
Authors
Loading...
Does not support clinical use of COX-2 inhibitors; leaves open selective COX-1 inhibition as hypothesis-generating for human atherosclerosis trials.
Does selective inhibition of COX-1 or COX-2 reduce atherosclerosis development and platelet vessel wall interactions in apoE-/- mice?
In an apoE-/- mouse model, COX-1 inhibition reduces early atherosclerotic lesion formation, whereas COX-2 inhibition does not affect lesion development or platelet-vessel wall interactions.
Belton et al. (2003) studied Atherosclerosis. Selective COX-1 inhibitor (SC-560) or selective COX-2 inhibitor (SC-236) vs. Vehicle was evaluated on Platelet vessel wall interactions and development of atherosclerosis. Selective inhibition of COX-1 reduced lesion formation in the early stages of atherosclerosis in apoE-/- mice, whereas COX-2 inhibition had no effect on lesion development.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: