Why the study?
Does age influence the time to loss of consciousness following a standard induction dose of midazolam in fit, unpremedicated patients?
Does age influence the time to loss of consciousness following a standard induction dose of midazolam in fit, unpremedicated patients?
Midazolam provides a more reliable and faster onset of anesthesia in elderly patients compared to younger patients.
Answers are grounded in this paper and cite their sources.
May inform age-specific midazolam dosing considerations; leaves open confirmation in randomized trials.
There was a considerable individual variation in response to a standard induction dose of 0.3 mg/kg midazolam in unpremedicated patients. This is shown by variations in time to onset of sleep and the fact that about one quarter of subjects did not lose consciousness in 3 minutes. In 166 fit patients a good negative correlation was demonstrated between the age of the patients and time to loss of consciousness. Patients over 50 years differed from younger patients in a greater reliability of effect and significantly shorter induction time. In elderly patients midazolam is a more reliable induction agent than in the young.
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DUNDEE et al. (1985) studied this question.
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