Why the study?
Does intravenous practolol reduce ventricular rate in patients with supraventricular dysrhythmias?
Does intravenous practolol reduce ventricular rate in patients with supraventricular dysrhythmias?
Intravenous practolol effectively and safely reduces rapid ventricular rates in patients with various supraventricular dysrhythmias by acting directly on the atrioventricular node.
May suggest rate reduction in supraventricular dysrhythmias; leaves open confirmation in randomized trials.
Practolol (I.C.I. 50172) was used to treat supraventricular dysrhythmias in 32 patients with a rapid ventricular rate and with heart disease of varied aetiology. In 26 patients the average reduction in ventricular rate was 75 per minute, while immediate reversion to sinus rhythm occurred in three patients. The slowing effect was mainly due to a direct action on the atrioventricular node. The effectiveness of practolol was unrelated to the type of dysrhythmia or its aetiology. No serious adverse clinical effects were noted.
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Gent et al. (1970) studied this question.
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