Key result
Children receiving maintenance therapy for acute lymphoblastic leukemia had significantly lower peak oxygen uptake (25.3 vs. 31.9 ml/kg/min; p<0.05) and quality of life than healthy controls.
Why the study?
Does maintenance therapy for acute lymphoblastic leukemia decrease functional capacity and quality of life in children compared to healthy controls?
Case-Control (n=30)
Does maintenance therapy for acute lymphoblastic leukemia decrease functional capacity and quality of life in children compared to healthy controls?
Children receiving maintenance therapy for ALL have reduced functional capacity and quality of life compared to healthy peers, though they retain sufficient capacity to participate in supervised exercise programs.
This is the authors' abstract. We don't add key points for this paper.
The purpose of this study was to determine if the functional capacity and quality of life of children receiving treatment against acute lymphoblastic leukemia (ALL) is decreased compared to healthy age and gender-matched children. Functional capacity was assessed with a number of measurements as the peak oxygen uptake (VO2peak) and ventilatory threshold determined during a ramp treadmill test, functional mobility (Timed Up and Down Stairs test [TUDS]) and ankle dorsiflexion passive and active range of motion (passive and active DF-ROM, respectively). Quality of life (QOL) was determined with the Spanish version of the Child Report Form of the Child Health and Illness Profile-Child Edition (CHIP-CE/CRF). Fifteen children (9 boys, 6 girls; mean [SD] age: 6.8 +/- 3.1 years) receiving maintenance therapy against ALL were studied and fifteen, nonathletic healthy children (9 boys, 6 girls; 6.9 +/- 3.3 years) were selected as controls. The mean values of VO2peak and active DF-ROM were significantly (p < 0.05) lower in patients (25.3 +/- 6.5 ml . kg (-1) . min (-1) vs. 31.9 +/- 6.8 ml . kg (-1) . min (-1) in controls and 19.6 +/- 8.0 degrees vs. 24.1 +/- 5.0 degrees , respectively). Children's self report of satisfaction (with self and health) (p < 0.05), comfort (concerning emotional and physical symptoms and limitations) (p < 0.01) and resilience (positive activities that promote health) (p < 0.01) were significantly decreased in patients with ALL. In summary, children receiving treatment against ALL have overall lower functional capacity and QOL than healthy children. However, their physical condition and health status are sufficiently high to allow them to participate in physical activities and supervised exercise programs.
Answers are grounded in this paper and cite their sources.
May support supervised exercise in ALL maintenance despite reduced capacity; leaves open causal mechanisms and need for prospective trials.
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Chamorro-Viña et al. (2008) conducted a case-control in Acute lymphoblastic leukemia (ALL) (n=30). Maintenance therapy for acute lymphoblastic leukemia vs. Healthy nonathletic children was evaluated on Peak oxygen uptake (VO2peak) (p=< 0.05). Children receiving maintenance therapy for acute lymphoblastic leukemia had significantly lower peak oxygen uptake (25.3 vs. 31.9 ml/kg/min; p<0.05) and quality of life than healthy controls.
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