Key result
Thrombin plays a multifaceted role in the development of complications after percutaneous coronary intervention, including restenosis and stent thrombosis.
This review highlights the multifaceted role of thrombin in post-PCI complications such as restenosis and stent thrombosis, emphasizing its involvement in inflammation, neoangiogenesis, and the potential of PAR-1 inhibitors.
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Thrombin modulation may merit exploration in post-PCI care; leaves open whether PAR-1 inhibition improves outcomes in prospective trials.
The purpose of this review is to increase the awareness of the experts about the multifaceted role of thrombin in the development of complications after percutaneous coronary intervention: restenosis and stent thrombosis. Here we present the analysis of clinical data obtained from 1990 to 2014, dealing with the study of basic mechanisms of thrombin action after angioplasty and coronary stenting, as well as the characteristics of the laboratory evaluation of thrombin generation and new antithrombotic drugs that block its activity. The article presents not only the original data, but also the personal view of the authors on the problem. The above information can be used in the learning process, as well as for the formation of new research directions and practical recommendations for physicians.
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Berezovskaya et al. (2015) conducted a review in Complications after percutaneous coronary intervention (restenosis and stent thrombosis). Thrombin was evaluated. Thrombin plays a multifaceted role in the development of complications after percutaneous coronary intervention, including restenosis and stent thrombosis.
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