Key result
A 77-year-old female developed radiation-induced angiosarcoma 8 years after breast-conserving surgery and radiation therapy, which was successfully treated with a right breast mastectomy.
Why the study?
Radiation-induced angiosarcoma is difficult to diagnose due to its rarity and non-specific symptoms, prompting examination of causative factors and management strategies.
Case Report (n=1)
This case report emphasizes the need for high clinical suspicion and prompt surgical management of radiation-induced angiosarcoma in patients presenting with breast skin changes after prior radiation therapy.
Answers are grounded in this paper and cite their sources.
Supports prompt mastectomy for radiation-induced breast angiosarcoma; leaves open optimal strategies pending larger studies.
We present a case of a 77-year-old female who was diagnosed with right breast invasive carcinoma treated with breastconserving surgery and adjuvant radiation therapy in 2015. In 2023, she was diagnosed with radiation-induced angiosarcoma (RIAS), and a right breast mastectomy was recommended. RIAS is difficult to diagnose due to its rarity and non-specific symptoms. This paper examines various factors causing RIAS and strategies to manage this disease. Even though achieving clear margins is challenging due to its multifocal nature, surgical resection remains the primary treatment for RIAS. The role of chemotherapy remains unclear, although targeted therapies may offer alternative options. The prognosis for RIAS is influenced by factors including the size of the tumor and stage at diagnosis. Adjuvant chemotherapy’s role is still evolving, and developments within radiotherapy approaches have allowed for enhanced local control. Further research is required to develop optimal treatment protocols and preventive strategies.
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Gaddipati et al. (2024) conducted a case report in Radiation-induced angiosarcoma of the breast (n=1). Right breast mastectomy was evaluated on Surgical resection outcome. A 77-year-old female developed radiation-induced angiosarcoma 8 years after breast-conserving surgery and radiation therapy, which was successfully treated with a right breast mastectomy.
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