Why the study?
Does the presence of the A allele at the nNOS gene rs41279104 sequence increase the risk of recurrent cardiovascular events in patients after STEMI?
Cohort (n=331)
Does the presence of the A allele at the nNOS gene rs41279104 sequence increase the risk of recurrent cardiovascular events in patients after STEMI?
The presence of the A allele at the nNOS gene rs41279104 sequence is associated with impaired endothelial function, increased sympathetic tone, and a higher incidence of recurrent cardiovascular events after STEMI.
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Resende et al. (2015) conducted a cohort in ST-elevation myocardial infarction (STEMI) (n=331). A allele at nNOS gene rs41279104 sequence vs. Non-carriers was evaluated on Fatal and non-fatal myocardial infarction, unstable angina with hospitalization and cardiac sudden death (RR 1.96, 95% CI 1.33-2.90, p=0.001).
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