Implementation of Raman Spectroscopy as an Analytical Tool Throughout the Synthesis of Solid-Phase Scaffolds

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Raman spectroscopy has been implemented as an extremely powerful tool for the vibrational analysis of solid-phase synthesis. In this report, the application of both on-line and batch-mode Raman analysis is presented for the comprehensive characterization of a multi-step small-molecule synthesis. Throughout this application, near-infrared Raman spectroscopy also provides unprecedented utility for on-bead qualitative and quantitative investigations. Finally, the on-line experimental procedure presents the first opportunity for open-loop feedback control of solid-phase synthetic parameters through the real-time presentation of reaction progression using Raman spectroscopy.