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January 1, 1984The Tohoku Journal of Experimental MedicineOpen Access

Effects of high-K low-Na, diltiazem, caffeine and Ba on spontaneous fluctuating contractile activities in rat cardiac muscle.

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Population

Isolated right ventricular trabecular muscles from Sprague-Dawley male rats weighing 200-250 g

Comparison

Perfusion with high-K low-Na solution, caffeine… vs Perfusion with normal control solution

Design

Preclinical

Authors

NINobumasa IshideUniversity of WashingtonHWHajime WatanabeTokyo Institute of TechnologyTTTamotsu TakishimaBoston University

Discussion

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Implication

Rat data implicate Na/Ca exchange in modulating spontaneous Ca oscillations; human relevance and therapeutic implications remain untested.

Structured PICO

P
Population
Isolated right ventricular trabecular muscles from Sprague-Dawley male rats weighing 200-250 g
I
Intervention
Perfusion with high-K (124 mM) low-Na (25 mM) solution, caffeine (0.5-10 mM), diltiazem (0.1 mM or 1 mM), and Ba (2.0 mM) without Ca
C
Comparator
Perfusion with normal control solution (Na 144 mM, K 5 mM, Cl 126 mM, Mg 1.2 mM, HCO3 25 mM, H2PO4 1.2 mM, glucose 10 mM, Ca 2.0 mM)
O
Outcome
Spontaneous fluctuating contractile activity measured by root mean square (RMS) values of light intensity fluctuationssurrogate

Spontaneous fluctuating contractile activity in rat myocardium is driven by cyclic Ca movements between the sarcoplasmic reticulum and contractile machinery, modulated by Na/Ca exchange.

Limitations

  • Methods employed were semi-quantitative
  • Measured active tensions depend on the compliance of the muscle ends

Cite This Study

Ishide et al. (1984) studied this question.

synapsesocial.com/papers/6a8431727e95b97f4e72fb22https://doi.org/10.1620/tjem.144.331
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diastolic scattered light fluctuation, resting force and twitch force in mammalian cardiac muscle1981 · 113 citations
  2. 2Contractions induced by a calcium‐triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells.1975 · 683 citations
  3. 3Cellular calcium turnover in the perfused rat heart: modulation by caffeine and procaine.1982 · 26 citations
  4. 4Dynamic stiffness of cat heart muscle in Ba2+-induced contracture.1978 · 40 citations
  5. 5Transient depolarization and spontaneous voltage fluctuations in isolated single cells from guinea pig ventricles. Calcium-mediated membrane potential fluctuations.1982 · 182 citations