Synthesis and Evaluation of Anticancer Activity of Indazole Derivatives

A novel series of indazole 13a – 13j derivatives has been synthesized. Their structures are confirmed by 1 H and 13 C NMR, and mass spectral analysis. The compounds are tested for their anticancer activity against four human cancer cell lines including A549 (Lung), MCF7 (Breast), A375 (Melanoma), and HT-29 (Colon), using combretastatin-A4 as a positive control. Most of the synthesized compounds demonstrate potent activity against the above cell lines. Here IC 50 values of target compounds range from 0.010±0.0042 to 12.8±3.77 μM and the control drug from 0.11±0.02 to 0.93±0.034 μM. The compounds 13a , 13b , 13e , 13g , 13h , and 13j are determined to be more potent than the positive control.