Who needs copper? There is a strong demand for ligation reactions that proceed spontaneously, selectively, and under physiological conditions. To meet these criteria, we used trifluoromethyl-substituted oxanorbornadienes in reactions with various azides, and achieved an elegant tandem [3+2] cycloaddition–retro-Diels–Alder reaction that forms stable 1,2,3-triazole-linked bioconjugates (see scheme).
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Berkel et al. (2007) studied this question.
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