Trans-ancestry GWAS identifies 59 loci and improves risk prediction and fine-mapping for kidney stone disease

, those in the lowest and highest quintiles exhibit distinct kidney stone disease risks with odds ratios of 0.57 (0.51-0.63) and 1.83 (1.68-1.98), respectively. Our results suggest that kidney stone disease patients with higher polygenic risk scores are younger at onset. In summary, our study advances the understanding of kidney stone disease genetic architecture and improves its genetic predictability.