Noradrenaline exerts its positive inotropic effect on the myocardium by increasing the rate of calcium uptake by the sarcoplasmic reticulum.
Reinforces noradrenaline inotropy mechanism in animals; leaves open translation to human cardiac therapy.
It is known that noradrenaline has a profound effect on myocardial contractility, but no satisfactory explanation of this process at a cellular level has been available previously. In this paper evidence is presented that noradrenaline increases the rate of uptake of calcium by the sarcoplasmic reticulum. The experimental findings correlate well with the effects of noradrenaline on cardiac contraction, and a hypothesis is suggested which explains the positive inotropic effect of the drug.
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Shinebourne et al. (1969) studied this question.
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