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This paper describes a method for the hydrolysis of the taurine conjugates of the 25R and the 25S diastereoisomers of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestan-26-oic acid (THCA) with retention of original configuration of C-25. Rat fecal suspensions were incubated with the taurine conjugate of THCA for 5 and 60% of the free THCA was recovered. When bile from Alligator mississippiensis, which contains mostly the taurine conjugate of THCA, was analyzed by this method, THCA was obtained with the 25R configuration.
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Batta et al. (1979) studied this question.
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