Population
Dogs (preclinical model)
Comparison
Changes in Po2 at the carotid body chemoreceptors vs Baseline Po2 (90 mm Hg)
Design
Preclinical
Authors
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May inform animal models of hypoxic ventilatory control; leaves open translation to human clinical applications.
A mathematical model using a nonlinear closed-loop feedback system with linear second-order dynamics accurately simulates the ventilatory response to hypoxia at the carotid bodies in dogs.
Smith et al. (1974) studied this question.
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