Tailored polyelectrolyte-supported asymmetric lipid-bilayer vesicles are prepared by layer-by-layer assembly onto colloidal templates (see Figure). The inner and outer leaflets are composed of different lipids. Both unilamellar and multilamellar lipid coatings are readily prepared by this approach, which may be useful in the construction of artificial cell-membrane models or drug-delivery systems with designed compositions and structures.
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Katagiri et al. (2005) studied this question.
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