Key result
Epicardial adipose tissue thickness in COPD patients is independently associated with increased systolic pulmonary artery pressure (P=0.002).
Why the study?
Pulmonary hypertension predicts mortality in COPD, and inflammation may contribute to its development. The authors tested whether epicardial adipose tissue thickness is associated with systolic pulmonary arterial pressure.
Is epicardial adipose tissue thickness associated with increased systolic pulmonary artery pressure in patients with COPD?
Observational (n=129)
Is epicardial adipose tissue thickness associated with increased systolic pulmonary artery pressure in patients with COPD?
Epicardial adipose tissue thickness is independently associated with increased systolic pulmonary artery pressure in COPD patients, suggesting a potential metabolic or inflammatory role in the development of pulmonary hypertension.
Answers are grounded in this paper and cite their sources.
Supports hypothesis of epicardial fat in COPD pulmonary hypertension; should not change practice without prospective studies.
Objectives Pulmonary hypertension (PHT) is one of the essential predictors of mortality in chronic obstructive pulmonary disease (COPD). It is thought that PHT is due to vasoconstriction secondary to hypoxia caused by airway obstruction in COPD patients; however, loss of capillary bed with emphysema, inflammation, and endothelial dysfunction may also play a role in the development of PHT. Epicardial adipose tissue (EAT) has a role as a metabolically active endocrine organ and secretes various proinflammatory cytokines. We hypothesized that EAT thickness in COPD patients might be associated with the systolic pulmonary arterial pressure (PAPs) level, and we aimed to test it. Methods The present study included 129 consecutive patients with the diagnosis of COPD. All patients underwent transthoracic echocardiographic evaluation. The relationship between PAPs and EAT thickness was evaluated. Results Positive correlations with PAPs were reported with age, EAT, white blood cell (WBC) and GOLD grade score (range 0.197‐0.275, P values 0.026 to 0.002), negative correlations with body‐mass index (BMI), hyperlipidemia, FEV 1 (% predicted) and pO2 (range −0.216 to −0.340, P values .014 to <.001). In stepwise linear regression analysis, BMI ( P = .003), EAT ( P = .002), WBC ( P = .001), and FEV 1 (% predicted) ( P = .010), were independently associated with PAPs. Conclusion EAT thickness in COPD patients with preserved left ventricular systolic function is associated with increased PAPs, and this association is independent of the parameters indicating the severity of COPD.
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Kalaycıoğlu et al. (2020) conducted an observational in chronic obstructive pulmonary disease (COPD) (n=129). Epicardial adipose tissue (EAT) thickness was evaluated on systolic pulmonary arterial pressure (PAPs) (p=0.002). Epicardial adipose tissue thickness in COPD patients is independently associated with increased systolic pulmonary artery pressure (P=0.002).
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