Controlling Curvature in a Family of Oligoamide α‐Helix Mimetics

Catching up with the curve! The natural curvature found in a majority of α helices has been mimicked in small synthetic oligoamide scaffolds. Differences in hydrogen-bonding patterns in these scaffolds lead to mimetics with varying degrees of curvature in the backbone. This adds another parameter to the structural and functional mimicry of α helices.