Key result
Total CSFV seroprevalence in 40,489 pig serum samples from China was 60.40% (95% CI: 59.92-60.88), with higher seroprevalence observed before the ASFV outbreak compared to after.
Why the study?
Surveillance of classic swine fever virus seroprevalence was needed to understand vaccine immune efficiency and herd health status, particularly following the 2018 African swine fever virus outbreak in China.
Cross-Sectional (n=40,489)
Yes
The study provides insights into the trends of CSFV antibody prevalence in China, particularly in relation to the ASFV outbreak, identifying key factors to improve vaccine efficiency.
Classic swine fever is a severe infectious and fatal disease in pigs caused by the classic swine fever virus (CSFV). Surveillance and investigation for CSFV seroprevalence contribute to knowing the immune efficiency of CSFV vaccines and reflect health status of swine herd, especially since the African swine fever virus (ASFV) outbreak in China in 2018. A total of 40,489 pig serum samples with related descriptive variables were obtained from 12 provinces and 2 cities of China from December 2017 to May 2021, covering before, during, and after three periods of ASFV outbreak. Pearson chi-square test and multivariable logistic regression analysis were used to identify impact factors related to variations in CSFV seroprevalence. Total CSFV seroprevalence was 60.40% (95% confidence interval: 59.92-60.88). Seroprevalence and antibody blocking rate mean of CSFV before outbreak of ASFV in China are higher and change gently compared with that after outbreak of ASFV. Serum collected from "summer and autumn," "north, southwest and northwest of China," "pig farm located in hill or mountain," " period before outbreak of ASFV," "PRRSV negative farm," and "replacement gilts, multiparous sows and boars" show high seroprevalence of CSFV. These results show trends in prevalence of CSFV antibody in recent years in China, especially when ASFV entered China. Identified impact factors provide references for improving immune efficiency of CSFV vaccine and benefit for prevention of CSFV.
No takes yet. Share an insight, caveat, or question.
Zhao et al. (2022) conducted a cross-sectional in Classic swine fever virus (CSFV) seroprevalence (n=40,489). Time period relative to ASFV outbreak vs. Before vs after outbreak was evaluated on Total CSFV seroprevalence (95% CI 59.92-60.88). Total CSFV seroprevalence in 40,489 pig serum samples from China was 60.40% (95% CI: 59.92-60.88), with higher seroprevalence observed before the ASFV outbreak compared to after.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: