Key result
Intravenous potassium supplementation rapidly resolved bilateral lower extremity weakness in a 49-year-old male with rare T3 thyrotoxicosis-induced periodic paralysis.
Why the study?
To present the different types of periodic paralysis syndromes alongside a unique case of T3 thyrotoxicosis causing periodic paralysis.
Case Report (n=1)
T3 thyrotoxicosis is a rare but important cause of thyrotoxic periodic paralysis that responds rapidly to potassium supplementation and requires definitive management of the underlying hyperthyroidism.
Prompts T3 thyrotoxicosis consideration in TPP; hypothesis-generating case leaves broader applicability open.
Description Periodic paralysis is a group of muscle diseases that are related to transmembrane ion channels. Dysfunction of these channels causes an increase in sodium-potassium (Na-K) adenosine triphosphatase (ATPase) activity that pushes potassium into the cells that result in serum hypokalemia that manifests as muscle weakness. Beta-adrenergic stimulation and insulin sensitivity might also play a role. Periodic paralysis is divided into hereditary and acquired forms. Thyrotoxic periodic paralysis is an acquired form of periodic paralysis that manifests as muscle weakness, hypokalemia, and hyperthyroidism. The onset of the symptoms is mainly over the age of 20 and can be triggered by intense physical activity, stress, and excessive carbohydrate intake. This review presents the different types of this disease (hypokalemic, hyperkalemic, thyrotoxic, and Andersen-Tawil syndrome) while presenting a unique case of T3 thyrotoxicosis causing periodic paralysis.
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Chao et al. (2020) conducted a case report in T3 Thyrotoxicosis causing Periodic Paralysis (n=1). Intravenous potassium and magnesium was evaluated on Symptom improvement. Intravenous potassium supplementation rapidly resolved bilateral lower extremity weakness in a 49-year-old male with rare T3 thyrotoxicosis-induced periodic paralysis.
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