Key result
Nav1.5 protein was localized in distinct regions of the mouse brain and co-localized with neurofilaments at high density in neuronal processes, mainly axons.
The cardiac sodium channel Na(v)1.5 is also localized in specific regions and axons of the mouse brain, suggesting a role in central nervous system electrical signaling.
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Nav1.5 localization to mouse brain axons supports possible CNS signaling roles; hypothesis-generating for human neuronal function.
Na(v)1.5 or SCN5A is a member of the voltage-dependent family of sodium channels. The distribution of Na(v)1.5 protein was investigated in the mouse brain using immunohistochemistry. Immunostaining with a Na(v)1.5-specific antibody revealed that Na(v)1.5 protein was localized in certain distinct regions of brain including the cerebral cortex, thalamus, hypothalamus, basal ganglia, cerebellum and brain stem. Notably, we found that Na(v)1.5 protein co-localized with neurofilaments and clustered at a high density in the neuronal processes, mainly axons. These results suggest that Na(v)1.5 protein may play a role in the physiology of the central nervous system (generation and propagation of electrical signals by axons).
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Wu et al. (2002) studied this question. Immunohistochemistry for Nav1.5 protein was evaluated on Localization of Nav1.5 protein in the mouse brain. Nav1.5 protein was localized in distinct regions of the mouse brain and co-localized with neurofilaments at high density in neuronal processes, mainly axons.
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