Key result
Higher plasma total adiponectin levels were associated with a reduced risk of incident type 2 diabetes (OR 0.59; 95% CI 0.51-0.68 per 1 SD increment), whereas ADIPOQ variants showed no association.
Why the study?
Are plasma adiponectin levels and ADIPOQ variants associated with the incidence of type 2 diabetes in a general Japanese population?
Case-Control (n=1,614)
Are plasma adiponectin levels and ADIPOQ variants associated with the incidence of type 2 diabetes in a general Japanese population?
Higher plasma levels of total and high-molecular-weight adiponectin are strongly associated with a reduced risk of incident type 2 diabetes, independent of ADIPOQ variants.
Positions adiponectin as a potential biomarker for type 2 diabetes risk rather.
AIMS: To clarify the associations between plasma adiponectin levels and ADIPOQ variants with type 2 diabetes incidence in a general Japanese population. METHODS: We conducted a case-control study nested within the Japan Public Health Center-based Prospective Study. We measured plasma adiponectin levels and genotyped +45T>G (rs2241766) and +276G>T (rs1501299) in the ADIPOQ gene among 417 incident diabetes cases and 1197 control subjects matched by age, sex, and area. RESULTS: After potential confounding factor adjustment, the multivariable-adjusted diabetes odds ratios (ORs) were 0.59 (95% confidence interval [CI]: 0.51-0.68) and 0.68 (95% CI: 0.60-0.78) per 1 standard deviation increment in the log-transformed levels of total- and high-molecular-weight (HMW) adiponectin levels, respectively. However, the ADIPOQ variants were not significantly associated with plasma adiponectin levels (for total adiponectin, +45 P=0.15 and +276 P=0.08) and diabetes risk (+45 P=0.70 and +276 P=0.72) under the additive genetic model. CONCLUSIONS: Our prospective findings suggest that both total and HMW adiponectin levels are strongly and inversely associated with diabetes risk after adjustment for potential confounding factors; however, the ADIPOQ variants +45 and +276 are not associated with adiponectin levels and diabetes risk in the general Japanese population.
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Goto et al. (2017) conducted a case-control in type 2 diabetes (n=1,614). Plasma adiponectin levels and ADIPOQ variants vs. Lower adiponectin levels / reference genotypes was evaluated on type 2 diabetes incidence (OR 0.59, 95% CI 0.51-0.68). Higher plasma total adiponectin levels were associated with a reduced risk of incident type 2 diabetes (OR 0.59; 95% CI 0.51-0.68 per 1 SD increment), whereas ADIPOQ variants showed no association.
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