Highlights the importance of cytoskeleton regulation of ion channels in maintaining normal cardiac excitability and its role in arrhythmogenic syndromes.
C ardiac arrhythmia is one of the leading causes of sudden death in developed countries, and results from abnormal cardiac electric activity. Regular beat-to-beat cardiac excitability requires the coordinated activity of membranebound ionophoric proteins that are channels and transporters. Aberrant currents can result from either changes in the gating properties of ionophores or altered trafficking to their appropriate membrane subdomain. Mutations in the genes of ionophoric proteins result in inherited human arrhythmogenic syndromes. 3]
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A 2015 study conducted a review in Cardiac arrhythmia.
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