Key result
An accidental overdose of 15 mg of colchicine over 10 hours in a 32-year-old COVID-19 inpatient resulted in complete recovery of bilateral pneumonia and pericardial effusion.
Case Report (n=1)
No
An accidental 15 mg overdose of colchicine led to rapid clinical and radiological recovery of COVID-19 pneumonia and pericardial effusion, suggesting a potential role for high-dose colchicine in suppressing hyperinflammation.
Does not support practice change; hypothesis-generating for high-dose colchicine in hyperinflammatory states.
A 32-year-old patient with COVID-19 pneumonia and pericardial effusion mistakenly took 15 mg of colchicine over 10 hours. He developed diarrhea that resolved two days after colchicine was stopped. Remarkably, this single overdose of colchicine, without any additional therapy, resulted in the complete recovery of bilateral pneumonia and pericardial effusion, and the patient was discharged on the hospital day 9th. This case demonstrates the possibility that high colchicine doses may have a major role and a dramatic effect in the treatment of COVID-19 patients.
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Mondeshki et al. (2023) conducted a case report in COVID-19 pneumonia and pericardial effusion (n=1). Colchicine was evaluated on Recovery of bilateral pneumonia and pericardial effusion. An accidental overdose of 15 mg of colchicine over 10 hours in a 32-year-old COVID-19 inpatient resulted in complete recovery of bilateral pneumonia and pericardial effusion.
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