Key result
In patients with newly diagnosed type 2 diabetes, the estimated 10-year coronary heart disease risk significantly correlated with carotid intima-media thickness, flow-mediated dilation, and pulse wave velocity.
Why the study?
Do non-invasive vascular tests correlate with the UKPDS risk engine for cardiovascular risk assessment in patients with newly diagnosed type 2 diabetes?
Cross-Sectional (n=380)
No
Do non-invasive vascular tests correlate with the UKPDS risk engine for cardiovascular risk assessment in patients with newly diagnosed type 2 diabetes?
Effect estimate: r=0.282
p-value: p=<0.001
In patients with newly diagnosed type 2 diabetes, non-invasive vascular tests such as CIMT and FMD correlate with the UKPDS risk engine, supporting their use in early cardiovascular risk assessment.
Noninvasive vascular tests may aid early risk assessment in new T2D; leaves open prospective validation against outcomes.
BACKGROUND: Patients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD) risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes. METHODS: Participants (n=380; aged 20 to 81 years) with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD) and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT), flow mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AI) were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis. RESULTS: The mean 10-year CHD and 10-year stroke risks were 14.92±11.53% and 4.03±3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001), FMD (P=0.017), and PWV (P=0.35) after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001) after adjusting for age. FMD correlated with age (P<0.01) and systolic blood pressure (P=0.09). CIMT correlated with age (P<0.01), HbA1c (P=0.05), and gender (P<0.01). CONCLUSION: The CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.
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Seon et al. (2011) conducted a cross-sectional in Newly diagnosed type 2 diabetes (n=380). UKPDS risk engine 10-year CHD risk was evaluated on Correlation between 10-year coronary heart disease (CHD) risk and carotid intima-media thickness (CIMT) after adjusting for age (r=0.282, p=<0.001). In patients with newly diagnosed type 2 diabetes, the estimated 10-year coronary heart disease risk significantly correlated with carotid intima-media thickness, flow-mediated dilation, and pulse wave velocity.
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