Metabolomics Methods as a New Diagnostic Tool for Thyroid Nodules

undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS) (III), follicular neoplasm (FN) or suspicious for FN (IV), suspicious for malignancy (V), and malignant (VI) The risk of malignant changes for each of these groups is as follows: I-1-4%, II-0-3%, III-5-15%, IV-15-30%, V-60-75%, and VI-97-99%. AUS, FLUS, FN and suspicion of malignancy are recognized in 5-42% of cases and act together to form an indeterminate diagnosis; they are all indications for diagnostic surgery