Detecting heparin: We report a new fluorescent approach to the detection and quantification of the biologically relevant molecule heparin. We designed and prepared a cyclic peptide that is able to catalyse the hydrolysis of a fluorogenic anionic ester (green) under low-concentration conditions. Then we demonstrated that the inhibition of this artificial enzyme (grey) by heparin (red) allows its fluorescent sensing with a remarkable sensitivity of 13 nM.
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Vial et al. (2008) studied this question.
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