Key result
The rs10500279 variant in the RYR1 gene was significantly associated with electrocardiographic left ventricular hypertrophy (OR 1.58; 95% CI 1.35-1.85; P=1.0x10^-8).
Why the study?
Are common variants in the RYR1 gene associated with electrocardiographic left ventricular hypertrophy?
Case-Control (n=9,634)
Yes
Are common variants in the RYR1 gene associated with electrocardiographic left ventricular hypertrophy?
Odds Ratio: 1.58 (95% CI 1.35–1.85)
p-value: p=1.0 × 10(-8)
Common variants in the RYR1 gene, which encodes a skeletal muscle calcium channel, are significantly associated with the development of electrocardiographic left ventricular hypertrophy.
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Identifies a novel genetic risk marker for LVH that should not yet change.
Hong et al. (2011) conducted a case-control in Electrocardiographic left ventricular hypertrophy (ECG-LVH) (n=9,634). RYR1 gene variant rs10500279 vs. Controls was evaluated on Electrocardiographic left ventricular hypertrophy (ECG-LVH) (OR 1.58, 95% CI 1.35-1.85, p=1.0 × 10(-8)). The rs10500279 variant in the RYR1 gene was significantly associated with electrocardiographic left ventricular hypertrophy (OR 1.58; 95% CI 1.35-1.85; P=1.0x10^-8).
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