Key result
HIV-positive men receiving antiretroviral therapies exhibited resting cardiac dysfunction, altered cardiac responses to exercise, and depressed exercise tolerance compared to matched healthy controls.
Why the study?
Does HIV infection and antiretroviral therapy affect resting and exercise cardiac function and exercise tolerance in asymptomatic men compared to matched healthy controls?
Case-Control
Does HIV infection and antiretroviral therapy affect resting and exercise cardiac function and exercise tolerance in asymptomatic men compared to matched healthy controls?
Asymptomatic HIV-positive men on antiretroviral therapy exhibit subclinical resting and exercise-induced cardiac dysfunction and reduced exercise tolerance.
Alerts clinicians to subclinical dysfunction in asymptomatic HIV patients on ART; leaves open need for prospective outcome studies.
Resting and exercise cardiac function, skeletal muscle oxygenation and whole-body aerobic exercise capacities were evaluated prospectively in cardiac symptom-free HIV men receiving antiretroviral therapies and in healthy controls matched for age, physical activity, smoking and body surface area. HIV patients showed resting cardiac dysfunction, altered cardiac responses to exercise and depressed exercise tolerance. Exercise stroke volume kinetics and muscle oxygenation were impaired in HIV patients, especially in those with resting diastolic dysfunction.
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Thöni et al. (2008) conducted a case-control in HIV. HIV infection and combined antiretroviral therapies vs. Healthy controls matched for age, physical activity, smoking and body surface area was evaluated on Resting and exercise cardiac function, skeletal muscle oxygenation and whole-body aerobic exercise capacities. HIV-positive men receiving antiretroviral therapies exhibited resting cardiac dysfunction, altered cardiac responses to exercise, and depressed exercise tolerance compared to matched healthy controls.
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