Key result
A literature review of antiarrhythmic drug dosing in children summarized published dosage recommendations to address the scarcity of official guidelines and prevent dosing uncertainties.
Why the study?
Official guidelines and consensus documents on pediatric antiarrhythmic drug dosing remain scarce, with only very broad dosage recommendations for several medications.
What are the published dosage recommendations for antiarrhythmic drugs in children?
What are the published dosage recommendations for antiarrhythmic drugs in children?
This review summarizes pediatric antiarrhythmic drug dosing recommendations to prevent uncertainties and errors, encouraging centers to develop specific protocols.
May guide pediatric antiarrhythmic dosing where guidelines are scarce; leaves open need for formal consensus and trials.
Antiarrhythmic drugs represent a mainstay of pediatric arrhythmia treatment. However, official guidelines and consensus documents on this topic remain scarce. There are rather uniform recommendations for some medications (including adenosine, amiodarone, and esmolol), while there are only very broad dosage recommendations for others (such as sotalol or digoxin). To prevent potential uncertainties and even mistakes with regard to dosing, we summarized the published dosage recommendations for antiarrhythmic drugs in children. Because of the wide variations in availability, regulatory approval, and experience, we encourage centers to develop their own specific protocols for pediatric antiarrhythmic drug therapy.
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Oeffl et al. (2023) conducted a review in pediatric arrhythmia. Antiarrhythmic drugs was evaluated. A literature review of antiarrhythmic drug dosing in children summarized published dosage recommendations to address the scarcity of official guidelines and prevent dosing uncertainties.
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