Key result
Compared to full crystalloid infusion, combined crystalloid and colloid solutions significantly reduced the postoperative decline in colloid osmotic pressure and albumin levels in elderly patients undergoing major abdominal surgery.
Why the study?
To explore the effects of different infusion schemes on colloid osmotic pressure during major abdominal surgery and perioperative albumin in elderly patients.
Does a mixed crystalloid-colloid infusion strategy improve perioperative colloid osmotic pressure and albumin levels compared to a crystalloid-only strategy in elderly patients undergoing major abdominal surgery?
Population
140 elderly patients of 65-80 years old undergoing major abdominal surgery
Comparison
Whole crystal vs crystal-colloid ratio 1:1 vs 2:1 vs 1:2
Design
Randomized trial
Authors
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Favors mixed crystalloid-colloid over crystalloid alone to preserve osmotic pressure in elderly abdominal surgery; extends RCT evidence for balanced perioperative fluids.
RCT (n=140)
Single-blind
Random number table
No
Does a mixed crystalloid-colloid infusion strategy improve perioperative colloid osmotic pressure and albumin levels compared to a crystalloid-only strategy in elderly patients undergoing major abdominal surgery?
Absolute Event Rate: 1.5% vs 11.9%
p-value: p=<0.01
In elderly patients undergoing major abdominal surgery, a mixed crystalloid-colloid fluid strategy better preserves colloid osmotic pressure and serum albumin compared to a crystalloid-only strategy.
Zhao et al. (2020) conducted an RCT in Elderly patients undergoing major abdominal surgery (n=140). Crystalloid-colloid combination solutions vs. Full crystalloid solution was evaluated on Postoperative decline of colloid osmotic pressure (Group C [2:1 ratio] vs Group A [full crystal]) (p=<0.01). Compared to full crystalloid infusion, combined crystalloid and colloid solutions significantly reduced the postoperative decline in colloid osmotic pressure and albumin levels in elderly patients undergoing major abdominal surgery.