What question did this study set out to answer?

To examine whether the traditional Chinese medicine Xiao-Chai-Hu-Tang protects against diabetic nephropathy in type-1 diabetic mice and cellular models.

January 1, 2012Evidence-based Complementary and Alternative MedicineOpen Access

Renal Protective Effect of Xiao-Chai-Hu-Tang on Diabetic Nephropathy of Type 1-Diabetic Mice

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Authors

CLChun-Ching LinKaohsiung Medical University LLLiang LinTaipei Medical University MYMing-Hong YenKaohsiung Medical University

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Implication

Preclinical study demonstrates improved renal function and reduced fibrosis in diabetic mice, suggesting therapeutic potential against diabetic kidney disease.

Key Points

To examine whether the traditional Chinese medicine Xiao-Chai-Hu-Tang protects against diabetic nephropathy in type-1 diabetic mice and cellular models.
Administered oral Xiao-Chai-Hu-Tang for 4 weeks to streptozotocin-induced diabetic mice and evaluated renal function, renal hypertrophy, and serum glucose against vehicle treatment.
Treated high-glucose-exposed rat mesangial cells with Xiao-Chai-Hu-Tang and quantified reactive oxygen species and free radical scavenging using DPPH assays, DHE staining, and CM-H2DCFDA analysis.
Improved renal functions and renal hypertrophy in diabetic mice with only moderate reductions in serum glucose relative to vehicle treatment.
Decreased renal and cellular expression of TGF-β1, fibronectin, and collagen IV while concurrently increasing BMP-7 expression.
Scavenged free radicals and inhibited high-glucose-induced reactive oxygen species production in rat mesangial cells.

Cite This Study

Lin et al. (2012) studied this question.

synapsesocial.com/papers/6a847f68cdf3a848bdbd91e3 https://doi.org/10.1155/2012/984024

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Implication

Preclinical study demonstrates improved renal function and reduced fibrosis in diabetic mice, suggesting therapeutic potential against diabetic kidney disease.

Renal Protective Effect of Xiao-Chai-Hu-Tang on Diabetic Nephropathy of Type 1-Diabetic Mice

Discussion

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Implication

Key Points

Cite This Study

Renal Protective Effect of Xiao-Chai-Hu-Tang on Diabetic Nephropathy of Type 1-Diabetic Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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