The interaction between an RNA model phosphodiester and oxovanadate complexes results in a purely hydrolytic cleavage of a phosphodiester bond under physiological pH and temperature: a comparison of the rate-pH profile with the species distribution diagram indicates that the negatively charged tetravanadate [V(4)O(12)](4-), which forms at toxic vanadium levels, is the hydrolytically active species.
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Steens et al. (2008) studied this question.
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