Key result
Mathematical modeling of HFMD in Wenzhou, China, indicates that EV-A71 vaccination slightly reduces incidence but does not lead to disease extinction without additional control measures.
Why the study?
The dynamics and optimal control strategies of hand, foot, and mouth disease incorporating EV-A71 vaccination in Wenzhou, China, required analytical and numerical investigation.
Mathematical modeling suggests that EV-A71 vaccination alone is insufficient to eradicate HFMD in Wenzhou, requiring additional measures like decreasing contact rates.
In this paper, we investigate the dynamics and optimal control strategies of a modified hand, foot, and mouth disease (HFMD) model incorporating the EV-A71 vaccination in Wenzhou, China, analytically and numerically. We define the basic reproduction number R0 and show that it can be used to determine whether HFMD becomes extinct or not. Based on the monthly reported HFMD cases in Wenzhou for 76 months, we estimate the parameters in the dynamic model by using the method of minimum chi-square fitting, conduct the sensitivity analysis to investigate the influence of each uncertain parameter on R0 with the methods of Latin hypercube sampling and partial rank correlation coefficient, and find that the EV-A71 vaccination does not lead to the extinction of HFMD, but slightly reduces the incidence of HFMD. In order to control the spread of HFMD in Wenzhou, we need to increase the rate of EV-A71 vaccination, decrease the contact rates, and shorten the course of disease.
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Ding et al. (2020) studied Hand, foot, and mouth disease (HFMD). EV-A71 vaccination was evaluated on Basic reproduction number and HFMD incidence. Mathematical modeling of HFMD in Wenzhou, China, indicates that EV-A71 vaccination slightly reduces incidence but does not lead to disease extinction without additional control measures.
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