PO₄³⁻ Coordinated Robust Single‐Atom Platinum Catalyst for Selective Polyol Oxidation**

Achieving efficient catalytic conversion over a heterogeneous catalyst with excellent resistance against leaching is still a grand challenge for sustainable chemical synthesis in aqueous solution. Herein, we devised a single‐atom Pt 1 /hydroxyapatite (HAP) catalyst via a simple hydrothermal strategy. Gratifyingly, this robust Pt 1 /HAP catalyst exhibits remarkable catalytic selectivity and catalyst stability for the selective oxidation of C 2 –C 4 polyols to corresponding primary hydroxy acids. It is found that the Pt−(O−P) linkages with strong electron‐withdrawing function of PO 4 3− (Pt 1 −OPO 4 3− pair active site) not only realize the activation of the C−H bond, but also destabilize the transition state from adsorbed hydroxy acids toward the C−C cleavage, resulting in the sharply increased selectivity of hydroxy acids. Moreover, the strong PO 4 3− ‐coordination effect provides electrostatic stabilization for single‐atom Pt, ensuring the highly efficient catalysis of Pt 1 /HAP for over 160 hours with superior leaching resistance.