Neodymium (Nd 3+ )‐sensitized nanoconstructs have gained increasing attention in recent decades due to their unique properties, especially optical properties. The design of various Nd 3+ ‐sensitized nanosystems is expected to contribute to medical and health applications, due to their advantageous properties such as high penetration depth, excellent photostability, non‐photobleaching, low cytotoxicity, etc. However, the low conversion efficiency and potential long‐term toxicity of Nd 3+ ‐sensitized nanoconstructs are huge obstacles to their clinical translations. This review article summarizes three energy transfer pathways of all kinds of Nd 3+ ‐sensitized nanoconstructs focusing on the properties of Nd 3+ ions and discusses their recent potential applications as near‐infrared (NIR) enabled photomedicine. This review article will contribute to the design and fabrication of novel Nd 3+ ‐sensitized nanoconstructs for NIR‐enabled photomedicine, aiming for potentially safer and more efficient designs to get closer to clinical usage.
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Yu et al. (2019) studied this question.
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