August 1, 1987AJP Heart and Circulatory Physiology

Nonhuman primate model for regional wave travel and reflections along aortas

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Population

5 mature anesthetized baboons (Papio anubis)

Design

Preclinical

Authors

RLR LathamUniversity of Tasmania NWNicolaas WesterhofBrooke Army Medical Center PSP. SipkemaRijnstate Hospital

Discussion

Member takes

Implication

Baboons show lower aortic impedance and reflections than middle-aged humans; challenges suitability of this model for human wave reflection studies.

Structured PICO

Population

5 mature anesthetized baboons (Papio anubis)

Intervention

Multisensor micromanometry and aortography to measure arterial pulse transmission and wave reflections

Outcome

Arterial pulse transmission characteristics including aortic input impedance, regional foot-to-foot and apparent phase velocities, and local reflection coefficientssurrogate

The baboon model is not suitable for studying proximal systemic reflective characteristics of normal middle-aged humans due to significant differences in wave reflection and impedance.

Limitations

The baboon is not a good model for the proximal systemic reflective characteristics of normal middle-aged humans

Cite This Study

Latham et al. (1987) studied this question.

synapsesocial.com/papers/6a8490c174ee596ff2c52977 https://doi.org/10.1152/ajpheart.1987.253.2.h299

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Implication

Baboons show lower aortic impedance and reflections than middle-aged humans; challenges suitability of this model for human wave reflection studies.

Nonhuman primate model for regional wave travel and reflections along aortas

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Nonhuman primate model for regional wave travel and reflections along aortas

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider