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July 16, 2007The Journal of Cell BiologyOpen Access

G protein–independent Ras/PI3K/F-actin circuit regulates basic cell motility

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Population

Dictyostelium cells

Comparison

Genetic deletion of Gbeta, PTEN, PI3K, or… vs Wild-type Dictyostelium cells or vehicle-treated…

Design

Preclinical

Authors

ASAtsuo T. SasakiCJChris JanetopoulosSLSusan Lee

Discussion

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Overview

No immediate clinical implications for cardiovascular disease; leaves open whether this G protein-independent circuit operates in mammalian cardiac or vascular cells.

Structured PICO

P
Population
Dictyostelium cells (wild-type KAx-3, NC-4, gbeta null, pten null, pi3k1/2/3 null, aimless null, pianissimo null, akt null)
I
Intervention
Genetic deletion of Gbeta, PTEN, PI3K, or Aimless, and pharmacological inhibition with LY294002 or Latrunculin B
C
Comparator
Wild-type Dictyostelium cells or vehicle-treated cells
O
Outcome
Spontaneous PI3K and Ras activation, F-actin projection, and random cell movementsurrogate

A G protein-independent Ras/PI3K/F-actin positive feedback circuit regulates autonomous cell motility and cytokinesis.

Cite This Study

Sasaki et al. (2007) studied this question.

synapsesocial.com/papers/6a849ba663149f2fb08e3687https://doi.org/10.1083/jcb.200611138
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