SUMMARY The relationships of acetylhistamine and histamine to the clinical signs of carbohydrate-induced acidosis were investigated in beef steers. Blood pH and plasma l -lactic acid decreased and serum sodium, serum potassium, ruminal fluid l -lactic acid, ruminal fluid histamine, and ruminal fluid and blood acetylhistamine increased in carbohydrate-engorged steers as compared with the changes in the steers while feeding on pasture (forage-fed steers). Twelve to 14 hours after the steers had become engorged, clinical signs of laminitis (“feedlot founder”) were observed in three of six steers. These signs appeared 4 to 6 hours after blood acetylhistamine attained maximal concentration (2.9997 ± 1.7054 μg of histamine base/ml of blood) and blood pH decreased to 7.260 ± 0.026 at 8 hours after engorgement. Blood histamine value reached 0.1298 ± 0.1095 μg of histamine base/ml 4 hours after engorgement (8 to 10 hours before the appearance of clinical illness), but had reached maximal concentration 32 hours after engorgement (0.3300 ± 0.028 μg of histamine base/ml of blood).
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Suber et al. (1979) studied this question.