Highlights the potential role of maternal systemic lupus erythematosis as an environmental factor in the development of familial congenital complete heart block.
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May implicate maternal SLE in familial complete heart block; case report leaves open need for larger studies before changing etiologic evaluation.
A family is reported in which two siblings had congenital complete heart block with resultant congestive heart failure, the father and paternal grandfather show adult-onset conduction defects, and the mother has systemic lupus erythematosis. The interaction of heredity and environment is discussed in this context. A review of the literature on familial complete heart block suggests that so-called pure congenital-onset familial heart block, originally felt to be genetic, may in fact have an important enivronmental component, specifically related to ongoing maternal factors such as systemic lupus erythematosis.
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Winkler et al. (1977) studied this question.
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