D-dimer Predicts Short-Term Functional Outcome in Acute Ischemic Stroke

Jin‐Hyung Lee; Kyung-Jin Kim; Meyung-Kug Kim; Bong-Goo Yoo

doi:10.18700/jnc.160084

February 21, 2017Journal of Neurocritical CareOpen Access

D-dimer Predicts Short-Term Functional Outcome in Acute Ischemic Stroke

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Why the study?

Does plasma D-dimer level at admission predict poor short-term functional outcome in patients with acute ischemic stroke?

Structured PICO

Does plasma D-dimer level at admission predict poor short-term functional outcome in patients with acute ischemic stroke?

P

Population

290 consecutive patients with acute ischemic stroke within 3 days after onset, mean age 67.0 years, 61.7% men. Exclusions included stroke >3 days after onset, unmeasured D-dimer, cerebral hemorrhage, febrile illness (pneumonia, sepsis), cancer, valvular heart disease grade ≥2, ESRD on dialysis, and loss to follow-up at 3 months.

I

Intervention

Measurement of fasting plasma D-dimer at admission (within 3 days of acute ischemic stroke onset).

O

Outcome

Short-term functional outcome at 3-months after stroke onset, measured by the modified Rankin Scale (mRS), with poor outcome defined as mRS > 2.hard clinical

Limitations

Lack of a normal control group for comparison.
Small number of patients with poor outcomes compared to those with good outcomes.
Single-center study, limiting generalizability to all ischemic stroke patients.
Lack of peripheral vascular ultrasound to exclude D-dimer elevation due to deep vein thrombosis.

Implication

Plasma D-dimer level at admission is a useful biomarker for predicting short-term poor functional outcome in acute ischemic stroke, though its predictive value may be confounded by initial stroke severity.

Abstract

The objective of the study was to evaluate the predictive value of plasma D-dimer at admission after acute ischemic stroke, and to assess its effect on short-term functional outcome.

Discussion

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Cite This Study

Lee et al. (2017) studied this question.

synapsesocial.com/papers/6a84b0b4c3be978f8d8da19c https://doi.org/10.18700/jnc.160084

View Full Paper

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D-dimer Predicts Short-Term Functional Outcome in Acute Ischemic Stroke

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

D-dimer Predicts Short-Term Functional Outcome in Acute Ischemic Stroke

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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